Had a scan on search and surprised there's not a thread on this...
Actors whose career was killed by one movie...
Just sitting here watching Godzilla (1998)
and was looking over Wiki while watching.
Maria Pitillo, who plays Audrey.

She had a decent career going for her. She'd been in a bunch of movies and TV shows... then, Godzilla happened, she got a Golden Raspberry for it... and well... that was that.
Since then she's had single episodes, in only 6 TV shows.
6 TV episodes in 18 years... after her career was initially made up of 11 TV series in recurring roles and almost 20 feature films.
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Got any more?
Actors whose career was killed by one movie...
Just sitting here watching Godzilla (1998)

Maria Pitillo, who plays Audrey.

She had a decent career going for her. She'd been in a bunch of movies and TV shows... then, Godzilla happened, she got a Golden Raspberry for it... and well... that was that.
Since then she's had single episodes, in only 6 TV shows.
6 TV episodes in 18 years... after her career was initially made up of 11 TV series in recurring roles and almost 20 feature films.
---
Got any more?