I've mentioned favorite actors in the past, but haven't really mentioned favorite actresses. I thought about it, and I'd say these are my favorite female-led films, ones from various decades, along with the actresses leading them:
1930s - Footlight Parade (Joan Blondell)
1940s - Ball of Fire (Barbara Stanwyck)
1950s - Auntie Mame (Rosalind Russell)
1960s - The Great Race (Natalie Wood)
1970s - Cabaret (Liza Minnelli)
1980s - Broadcast News (Holly Hunter)
1990s - Fried Green Tomatoes (Mary Stuart Masterson)
2000s - Zombieland (Emma Stone)
2010s - Frances Ha (Greta Gerwig)
2020s - Words on Bathroom Walls (Taylor Russell)
1930s - Footlight Parade (Joan Blondell)
1940s - Ball of Fire (Barbara Stanwyck)
1950s - Auntie Mame (Rosalind Russell)
1960s - The Great Race (Natalie Wood)
1970s - Cabaret (Liza Minnelli)
1980s - Broadcast News (Holly Hunter)
1990s - Fried Green Tomatoes (Mary Stuart Masterson)
2000s - Zombieland (Emma Stone)
2010s - Frances Ha (Greta Gerwig)
2020s - Words on Bathroom Walls (Taylor Russell)