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Don't you guys ever watch the "E! True Hollywood Story"? It was revealed in a where-are-they-now segment towards the end of their look at "Scooby-Doo" that Scrappy-Doo had to be put down in late 1994. He developed rabies and bit three children, surely only after severely annoying them first.
Shaggy was arrested and publically humiliated after exposing himself to Casey Kasem in an adult theater, Fred became a congressman from Iowa's Fifth District, Daphne became a fundamentalist Christian who retired from showbiz and now has nine children of her own (but no dogs), and Velma has become a mini-mogul after franchising a chain of laser-vision-correction retail outlets found mostly in suburban malls.
As for Scooby-Doo himself, his whereabouts were mostly unknown until this new movie was greenlit. He showed up at an open casting call and the producers had no choice but to cast THE Scooby-Doo as their Scooby-Doo. Apparently Adam West had commiserated with the pooch for years after being cut-out of any participation in the big-budget Warner Bros. series started in 1989 ("At least those dastardly fiends could throw me a cameo"), so Scooby was not going to make the same mistake.
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"Film is a disease. When it infects your bloodstream it takes over as the number one hormone. It bosses the enzymes, directs the pineal gland, plays Iago to your psyche. As with heroin, the antidote to Film is more Film." - Frank Capra