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According to Bloody Disgusting and Variety:
Variety details, “It seemed to some fans like the planned sequel was collapsing in real time. However, even before Barrera was fired, plans for the next Scream were being retooled. Ortega’s exit had required the creative team to make some alterations, according to individuals with knowledge, but there were still hopes that the actress might be convinced to come back for some sort of cameo. That no longer seems to be in the cards. Another source familiar with the franchise disputed this, saying Ortega was never in the mix for the new film.”
“James Vanderbilt and Guy Busick, the writers of the previous two Scream installments, will now work on a fresh draft to present to filmmakers,” Variety continues. “Some set pieces and twists may be preserved, but the movie will need to find new protagonists.”
Variety’s report also mentions Neve Campbell and Patrick Dempsey as actors the studio may potentially be interested in bringing into Scream 7, but they make it clear that neither actor has been in active negotiations up to this point. Dempsey hasn’t been seen in the franchise since Scream 3, while Campbell didn’t appear in Scream VI due to a salary dispute.
Scream and Scream VI directors Matt Bettinelli-Olpin and Tyler Gillett (Radio Silence) will remain on board as executive producers, as will Chad Villella.