It would have been kinda like "The Love Boat" in a lot of ways. Different guest stars would wander in each week, then leave. Here's an episode listing from a 1978 airing that could have been if Aaron Spelling or somebody had the guts to pull it off...

9:00, WAITING FOR GODOT - comedy
Vladimir and Estragon (Steve Landesberg and Billy Crystal)
encounter a divorcee (Linda Lavin), a magician (Don Ameche)
and two Dallas Cowboy Cheerleaders (Judy and Audrey
Landers) on the road. They don't know who Godot is either.
Special appearance by The Captain & Tennille performing
"Muskrat Love".

9:00, WAITING FOR GODOT - comedy
Vladimir and Estragon (Steve Landesberg and Billy Crystal)
encounter a divorcee (Linda Lavin), a magician (Don Ameche)
and two Dallas Cowboy Cheerleaders (Judy and Audrey
Landers) on the road. They don't know who Godot is either.
Special appearance by The Captain & Tennille performing
"Muskrat Love".
__________________
"Film is a disease. When it infects your bloodstream it takes over as the number one hormone. It bosses the enzymes, directs the pineal gland, plays Iago to your psyche. As with heroin, the antidote to Film is more Film." - Frank Capra
"Film is a disease. When it infects your bloodstream it takes over as the number one hormone. It bosses the enzymes, directs the pineal gland, plays Iago to your psyche. As with heroin, the antidote to Film is more Film." - Frank Capra