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Amistad - Sir Anthony Hopkin's speech about freedom gets me every time.
Eternal Sunshine of the Spotless Mind - It gets me when Jim Carrey and Kate Winslet are sitting in his head on the beach, waiting for everything to be erased.
LOTR: Fellowship of the Ring - When Frodo is standing at the river at the end, and Gandalf's voice comes in; and then when Sam struggles passionately to get to the boat to be with his friend - you can't beat that.
LOTR: Two Towers - Theoden's ride gets me because it's one of the most amazing things I've ever seen, and Sam's speech about having something to hold onto is priceless.
LOTR: Return of the King - Way too much to list. Frodo telling Sam to go home, Gandalf's speech about death, Frodo and Sam at the end of all things, Sam coming up to his house to meet his family - and much more than that.
Unbreakable - From the train station sequence to the end of the movie, I lose it.
The Family Man - In this one, Nicholas Cage gets transported to an alternate "suburban" existence for himself, and his daughter thinks he's an alien that was taken her dad somewhere. There is one scene in which they are playing together in the snow, and Cage is becoming quite happy with his new life, and his daughter tells him, "I knew you'd come back." There is nothing better.
The Last Samurai - The last charge is unbelievable, and the way it turns out gets me, because of all the symbolisms that is attributed to it.
Chocolat - The end really gets to me, when all the resolutions are coming through.