Well, while I do feel that The Wire was an ambitious, well-written show on the whole, it was still never a favorite of mine due to it being kind of low energy in general, and I felt that all the hyperbolic praise that it's been showered with over the years has lead some to turn a blind eye to its missteps, like the way that the out of place "This is America" line in its very first scene feels like bit of forced, grandiose, Nolan-esque "themespeak", which was pretty odd for a show that tended to avoid that otherwise.
I've always looked at that scene as being humor or something that someone in the ghetto might say out of being lost for words.