People can love Trump all they want but just because he once touted hydroxychloroquine as a snake oil cure, doesn't make it a miracle Covid drug. That's why the FDA didn't approve it use for Covid after clinical testing. The FDA's decision has to do with medical research, not with politics.
Testing/medical research on hydroxychloroquine is still ongoing. Just published in the International Journal of Infectious diseases (7-1-20).
http://www.ijidonline.com/article/S1...534-8/fulltext
Some highlights:
- According to a protocol-based treatment algorithm, among hospitalized patients, use of hydroxychloroquine alone and in combination with azithromycin was associated with a significant reduction in-hospital mortality compared to not receiving hydroxychloroquine.
- The postulated pathophysiology of COVID-19 of the initial viral infection phase followed by the hyperimmune response suggest potential benefit of early administration of hydroxychloroquine for its antiviral and antithrombotic properties
- In the present study, multivariate analysis performed using Cox regression modeling and propensity score matching to control for potential confounders affirmed that treatment with hydroxychloroquine alone and hydroxychloroquine in combination with azithromycin was associated with higher survival among patients with COVID-19.
- The benefits of hydroxychloroquine in our cohort as compared to previous studies maybe related to its use early in the disease course with standardized, and safe dosing, inclusion criteria, comorbidities, or larger cohort.
- Later therapy in patients that have already experienced hyperimmune response or critical illness is less likely to be of benefit.
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“Our analysis shows that using hydroxychloroquine helped saves lives,” said Steven Kalkanis, CEO, Henry Ford Medical Group and Senior Vice President and Chief Academic Officer of Henry Ford Health System. “As doctors and scientists, we look to the data for insight. And the data here is clear that there was benefit to using the drug as a treatment for sick, hospitalized patients.”
https://detroit.cbslocal.com/2020/07...19-death-rate/
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“In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine."
“We attribute our findings that differ from other studies to early treatment, and part of a combination of interventions that were done in supportive care of patients, including careful cardiac monitoring,” he said.
“Our dosing also differed from other studies not showing a benefit of the drug. And other studies are either not peer reviewed, have limited numbers of patients, different patient populations or other differences from our patients.”
https://www.bizpacreview.com/2020/07...eatment-942329
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"Dr. Takahisa Mikami and his team at Icahn School of Medicine at Mount Sinai in New York, NY, analyzed the outcomes of 6493 patients who had laboratory-confirmed COVID-19 in the New York City metropolitan area, according to the article appearing in the Journal of General Internal Medicine[1]
The researchers found that hydroxychloroquine decreased mortality hazard ratio by 47% percent."
"Use of hydroxychloroquine, a drug heavily promoted by US President Donald Trump, came under intense criticism after an article last month in the prestigious medical journal The Lancet raised alarms about the safety of the drug for treating COVID-19. The Lancet subsequently retracted[3] the study after the data used for the analysis came into question."
https://thinkpol.ca/2020/07/03/ny-st...atients-lives/