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I'm looking forward to this, Scorsese is one of my favourite directors, and it looks like a slight departure for him. I'm not familiar with the book, but I hope he pulls it off.
I'd also like to add that I'm something of a DeCaprio fan. I think he's a tremendous actor, and genuinely can't think of a bad performance he's given. The only film with him in that I didn't care for was Titanic, and he was miscast in that one anyway (way too young looking for Kate Winslet).