Robert De Niro or Dustin Hoffman in a movie with fat woman

I remember only one scene. The characted played by Robert De Niro (or Dustin Hoffman or somebody similar) is virgin man. The character is 35-40 years old, I think. He saw fat woman (perhaps prostitute), which was friend of other person, but I don't remember exactly. Then, they have sex (although it wasn’t showed probably) and he is glad, because it was his first time. It was typical road movie and I’m sure that it was during long travel and rather action movie than only comedy.

I think that it was typical road movie with a motel scene or something similar. Perhaps it was action movie (or comedy) from 90s or 2000s. Definitely USA. Perhaps it’s Mandela Effect and it isn’t any of these actors, but I’m sure mentioned scene. I am sure that it could be quite popular movie.

It isn't "Rain Man" definitely.

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Awakenings had DeNiro in it but I don't remember a fat hooker.

Whatever it is, I hope they used this as the tagline on the poster.

I doubt, but thank you. I have to remember more details.

40 Year-Old-Virgin 2005 with Steve Carell. He kind of had a Dustin Hoffman style haircut.

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You can't raise your voice when the lion gets here man.

I know, but it isn't, unfortunately. It was only short scene. The actress was similar to Margo Martindale or Brooke Elliott (something like mix two actresses, if I remember good). It will be tough to find.

Perhaps man similar to Dustin Hoffman was only brother or friend other character.

Could it be Steve Martin? It could be The Jerk (1979).

It isn't, but thank you for guess.

There is a movie I haven't seen--only know from trailers. "Shallow Hal" starring Jack Black. He has a spell or something put on him so he sees unattractive women as attractive. So he falls in love with a very overweight woman, thinking she looks like Gwyneth Paltrow.

The 2000 comedy Road Trip directed by Todd Phillips (The Joker) has such a scene, though no actors that could be possibly confused for DeNiro or Hoffman. DJ Qualls plays the character who loses his virginity to a large girl.

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"Film is a disease. When it infects your bloodstream it takes over as the number one hormone. It bosses the enzymes, directs the pineal gland, plays Iago to your psyche. As with heroin, the antidote to Film is more Film." - Frank Capra

"Road Trip" is very similar, but it isn't. I'm sure that fat woman wasn't African American, but Caucasian and it wasn't Mia Amber definitely. However, it is good suggestion.